STAT-Site® M Beta-Hydroxybutyrate (BHB) Analyzer


A quantitative β-Hydroxybutyrate test system for laboratories with low volume testing needs.

The STAT-Site® M B-HB analyzer from EKF Diagnostics is used for the quantitative determination of B-Hydroxybutyrate (Beta-Hydroxybutyrate (BHB)) in serum or plasma, aiding in the diagnosis and monitoring of ketoacidosis. It is composed of a reflectance photometer and dry-reagent test strips.

Beta-Hydroxybutyrate (BHB) is used to aid the diagnosis and monitoring of patients with ketosis (also known as ketoacidosis and diabetic ketoacidosis or DKA).

Ketosis occurs when the body begins to break down its stored fats in response to a low supply of energy (glucose). This process produces the ketone Beta-Hydroxybutyrate (BHB), which is further catabolized into acetoacetate and then into acetone.

Easy measurements in 3 steps


1.  Insert the test strip.


2.  Apply sample.


3. Read resultss in < 80 seconds.

  • Quantitative: Beta-Hydroxybutyrate (BHB) Analyzer results provide the best and earliest indicator of ketosis and resolution of ketoacidosis (DKA).
  • Reliable: Beta-Hydroxybutyrate (BHB) is 78% of all available ketones and provide a better tool for differentiating metabolic acidosis and monitoring response to therapy.
  • Improved Clinical Outcomes: Resulting in higher quality of patient care while reducing ER/ICU patient stay.
  • Fast: Platform delivers results within 80 seconds.
  • No lag time: Due to testing serum or plasma samples.

Because Beta-Hydroxybutyrate (BHB) accounts for approximately 78% of all ketones bodies present, and is the first one to be present during ketosis, it provides the clearest indication of a patient’s condition before and after treatment. For this reason it is a more appropriate test than traditional nitroprusside tests that measure only acetoacetate and acetone.

The STAT-Site M Beta-Hydroxybutyrate (BHB) Analyzer uses dry reagent strips to provide results in 80 seconds allowing patients displaying symptoms to be quickly diagnosed and then monitored on a regular basis.

The specificity of Beta-Hydroxybutyrate (BHB) Analyzer means that patients receive a higher quality of care while reducing stays in Emergency Rooms and Intensive Care Units.

Ordering Information

Description Reference Number Pack Qty
STAT-Site® M β-HB Meter 400400 1 Each
STAT-Site® M β-HB Starter Kit 400400SP 1 Each
Description Reference Number Pack Qty
STAT-Site® M β-HB Test Strips (Inc CODE Key) 401010 4 x 10 strips
STAT-Site® Controls 303000 2 x 3 mL (1 Low, 1 High)
STAT-Site® Linearity Check 303500 1 x 1 mL
STAT-Site® Diluent 202000 6 x 3 mL
Description Reference Number Pack Qty
STAT-Site® M β-HB Battery Pack (3 Volt, LI) 900905 5 Batteries


Key Features

Results within 80 seconds
Small 10 µL sample size
Quantitative results of β-HB


Methodology – Reflectance photometry

Principle – β-Hydroxybutyrate dehydrogenase

Sample Type – Serum or plasma

Sample Size – 10µL

Range – 0.0 – 2.0 mmol/L (without dilution)

Precision CV (Low Control) – 6.1 %

Precision CV (High Control) – 3.9 %

Calibration – Automatic (CODE Key)

Basic analyzer pack includes

Analyzer, one 3V Li battery (installed), one replacement 3V Li battery, user manual and warranty registration card.

Starter pack includes

Analyzer, one box of 40 test strips, one box of controls, one box of diluent and one box of linearity check.

Frequently asked questions

When the body begins to break down its stored fats in response to a low supply of energy (glucose) it produces the ketone β-Hydroxybutyrate, which is further catabolized into acetoacetate and then into acetone.

β-HB is a better test for ketosis and ketoacidosis than nitroprusside methods for a number of reasons:

  • The nitroprusside method detects less than 22% of the ketones present in ketosis. β-HB is the main ketone produced by the body (78%).
  • β-HB demonstrates excellent stability, making it the most reliable indicator of clinically relevant ketosis and ketoacidosis.
  • During ketosis, β-HB levels increase more than levels of acetone and acetoacetate, clearly indicating the patient’s trend in metabolic status.
  • Quantitative, objective β-Hydroxybutyrate results provide a better tool for differentiating metabolic acidosis and monitoring therapy.

People with type 1 diabetes may be at risk when they do not have enough insulin, a hormone the body uses to break down sugar (glucose) in the blood for energy. When the body senses glucose is not available, fat is broken down instead.

As fats are broken down, acids called ketones build up in the blood and urine. Ketones are poisonous in high levels. This condition is called ketoacidosis.

Blood glucose levels rise (usually higher than 200 mg/dL) because the liver makes glucose to try to combat the problem. However the cells cannot pull in that glucose without insulin.

Symptoms can include rapid deep breathing, dry skin and mouth, flushed face, fruity smelling breath, nausea, vomiting and stomach pain. Other symptoms that can occur are; Abdominal pain, breathing difficulty while lying down, decreased appetite, decreased consciousness, muscle stiffness and aches, dulled senses that may worsen to a coma and frequent urination and thirst that lasts throughout the day.

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